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Molecular modeling of 8-methoxy quinolone analogues by using quantitative structure activity relationship
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نویسنده
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Srivastava A. K. ,Pathak Vinay Kumar ,Srivastava Akanchha ,Pandey Avni
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منبع
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journal of saudi chemical society - 2010 - دوره : 14 - شماره : 2 - صفحه:217 -222
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چکیده
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Quantitative structure activity relationship (qsar) studies on a series of 8-methoxy quinolone are found to correlate well with steric parameters and electronic parameter. the results are critically discussed on the basis of regression data, pogliani factor q and cross validation technique. the results are found to be useful in discussing the mechanism of drug – receptor interaction. steric parameter ‘mr’ and electronic parameter ‘pz’ gives the best model.
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کلیدواژه
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QSAR; Steric parameters; Electronic parameter; Cytotoxicity
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آدرس
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University of Allahabad, Department of Chemistry, QSAR Research Laboratory, India, University of Allahabad, Department of Chemistry, QSAR Research Laboratory, India, University of Allahabad, Department of Chemistry, QSAR Research Laboratory, India, University of Allahabad, Department of Chemistry, QSAR Research Laboratory, India
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Authors
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