Some new quinazolin-4(3H)-one derivatives, synthesis and antitumor activity

Series of some new 2,3-disubstituted-6-iodo-3h-quinazolin-4-one derivatives was prepared and screened for their in vitro antitumor activity against the human breast cancer cell line (mcf-7), human cervix carcinoma cell line (hela), human liver cancer cell line (hepg2) and human colon cancer cell line hct-8. five compounds exhibited broad spectrum antitumor activity, better than the standard drug doxorubicin (cas-23214-92-8) against the four tested cell lines. in the present study, mcf-7 cell line was the most sensitive one, 12 compounds were good cytotoxic towards it. the best cytotoxic results were obtained with compounds bearing allyl and/or benzyl moiety at positions 2 and/or 3 of the quinazoline nucleus.