Synthesis and in vitro antibacterial activity of new oxoethylthio-1,3,4-oxadiazole derivatives

In the present investigation, a series of 2(4-pyridyl)-5[(aryl/heteroarylamino)-1-oxoethyl] thio-1,3,4-oxadiazole were synthesized using isonicotinohydrazide and substituted aryl/heteroaryl amines using pyridine as solvent. newly synthesized compounds were tested for their in vitro anti-tubercular activity against mycobacterium tuberculosis h37rv using the bactec 460 radiometric system. among the synthesized compounds, compounds 2(4-pyridyl)-5((2-nitrophenylamino)- 1-oxoethyl)thio-1,3,4-oxadiazole (5e), 2(4-pyridyl)-5((4-nitrophenylamino)-1-oxoethyl)thio- 1,3,4-oxadiazole (5g) and 2(4-pyridyl)-5((2-pyrrolylamino)-1-oxoethyl)thio-1,3,4-oxadiazole (5k) produced highest efficacy and exhibited >90% inhibition at a concentration of 0.0077, 0.0052 and 0.0089 μm, respectively. all the new compounds were pharmacologically evaluated for their in vitro antimicrobial activity.