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A QSAR STUDY ON BENZOXAZINONES, ANALOGUES OF EFAVIRENZ, FOR THE DISCOVERY OF POTENT HIV-1 REVERSRSE TRANSCRIPTASE INHIBITORS
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نویسنده
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Srivastava A.K. ,Khan Arbab A. ,Tripathi Abha ,Chaurasia Shraddha
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منبع
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journal of saudi chemical society - 2005 - دوره : 9 - شماره : 3 - صفحه:571 -574
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چکیده
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The anti hiv-1 activity of benzoxazinones, analogues of efavirenz, is analyzed in relation to their physicochemical and molecular properties. the activities of the compounds are found to be significantly correlated with steric parameter, molecular connectivity 1cv, hydrphobicity-logp and electronic parameter equalized electro negativity-xeq. the results are found to be useful in disussing the mechanism of drug-receptor interaction.
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آدرس
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University of Allahabad, QSAR Research Laboratory, Department of Chemistry, India, University of Allahabad, QSAR Research Laboratory, Department of Chemistry, India, University of Allahabad, QSAR Research Laboratory, Department of Chemistry, India, University of Allahabad, QSAR Research Laboratory, Department of Chemistry, India
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Authors
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