COMPETITION OF DIPOSITIVE METAL IONS FOR FE(III) BINDING SITES IN CHELATION THERAPY OF IRON LOAD

Iron overload is a condition in which excessive iron depositedin the liver, kidney and spleen of human beings in the patients of b thalassemia and sickle cell anemia. instead of its importance iron could be toxic when in excess, it damages the tissues. for the treatment of iron overload, a drug desferrioxamine mesylate has been used. it is linear trihydroxamic acid, a natural siderophore produced by streptomyces which removes the extra iron from body. salicylhydroxamate is a simple model of hydroxamate type siderophore. in present research salicylhydroxamate was used for the complexation with dipositive metal ions which are available in biological environments such as mn(ii), co(ii), ni(ii) and cu(ii). the aim of our work was to study the competition reactions between fe(iii) and other dipositive ions; to calculate the thermodynamic data of chelation of these metal ions complexes with hydroxamate by computer program and comparison with iron hydroxamte complexes.