Aquagenic Wrinkling of the Palms, two new cases from Saudi Arabia

Aquagenic wrinkling of the palms (awp) is a rare dermatologic disease. it was first described four decades ago as a potential test for cystic fibrosis (cf) by detecting “skin wrinkling” in response to water immersion. we are reporting two cases of awp diagnosed at derma clinic, riyadh, saudi arabia. the first case was a 9-year old girl and the second case was a 17-year adolescent male. the second case was associated with palmer hyperhidrosis. both patients denied any medication use. additionally, signs and symptoms suggesting cf were lacking. local dermatologists should be aware of rare conditions such as awp and lack of previous reports from the region may indicate under-reporting rather than lack of cases.