Botulinum toxin: Non cosmetic and off-label dermatological uses

Botulinum toxin (bt-a) is a neurotoxin which is produced by the gram-positive anaerobic bacterium clostridium botulinum. the efficacy of botulinum toxin in treating hyperhidrosis and the glabellar lines is well known and fda approved. because bt-a inhibits the release of acetylcholine and many other neurotransmitters such as norepinephrine and substance p at the level of nerve ending, this toxin has been used to treat a lot of dermatological disorders which are thought to be triggered by these neurotransmitters. in this article we are discussing the medical off-label uses of bt-a in dermatology.