Microneedle structure design and optimization using Genetic Algorithm

This paper presents a genetic algorithm (ga) based microneedle design and analysis. ga is an evolutionary optimization technique that mimics the natural biological evolution. the design of microneedle structure considers the shape of microneedle,material used,size of the array,the base of microneedle,the lumen base,the height of microneedle,the height of the lumen,and the height of the drug container or reservoir. the ga is executed in conjunction with ansys simulation system to assess the design specifications. the ga uses three operators which are reproduction,crossover and mutation to manipulate the genetic composition of the population. in this research,the microneedle is designed to meet a number of significant specifications such as nodal displacement,strain energy,equivalent stress and flow rate of the fluid / drug that flow through its channel / lumen. a comparison study is conducted to investigate the design of microneedle structure with and without the implementation of ga model. the results showed that ga is able to optimize the design parameters of microneedle and is capable to achieve the required specifications with better performance. © 2015,school of engineering,taylor’s university.