Lagrange Two-Dimensional Interpolation Method for Modeling Nanoparticle Formation During RESS Process

In the pharmaceutical industry, a great number of products are in the form of particulatesolids. since the mid-1980s, a new method of powder generation has appeared involvingcrystallisation with supercritical uids (scf). the rapid expansion of supercritical solutions(ress) is a promising new process for the production of small and uniform particles.several variables can inuence the ress process: the nozzle temperature, preexpansionpressure, the nozzle diameter, and geometry. in this work, a two-dimensional lagrange interpolationmethod has been proposed to describe the size of nanoparticle forming throughthe rapid expansion of supercritical solutions, as a function of preexpansion pressure andnozzle temperature.