quick, easy, cheap, effective, rugged, and safe method followed by ionic liquid-dispersive liquid–liquid microextraction for the determination of trace amount of bisphenol a in canned foods

Combination of the quick, easy, cheap, effective, rugged, and safe (quechers) method with ionic liquid-dispersive liquid–liquid microextraction (quechers-il-dllme) was developed as an extraction methodology to determine bisphenol a (bpa) in various canned food samples prior to high-performance liquid chromatography ultraviolet detection (hplc-uv). the potential variables affecting the microextraction recovery were considered in the optimization process. obtained results showed that 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([c6mim][tf2n]) is a better extraction solvent compared with 1-hexyl-3-methylimidazolium hexafluorophosphate ([c6mim][pf6]) and is more compatible with rp-hplc. under the optimum conditions, the method yielded a linear calibration curve ranging from 1.0 to 500 μl−1 with a determination coefficient (r 2) of 0.9993. enrichment factor for bpa was 98, and limit of detection was 0.1 μg l−1. the relative standard deviation percent (rsd%) for the intra-day and inter-day extraction and determination at 2.0, 20, and 200 μg l−1 levels of bpa was less than 7.2 % (n = 6) and 9.7 % (n = 6), respectively. finally, the proposed method was successfully applied for the extraction, cleanup, preconcentration, and determination of the bpa in different canned food samples, and satisfactory results were obtained (relative recovery ≥90 %).