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single-step multiresidue determination of β-lactam antibiotics and β-agonists in porcine muscle by liquid chromatography-tandem mass spectrometry
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نویسنده
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li juan ,chen yu ,su ying-qian ,ding xiao-ming ,xia wen-shan ,liu hong-min ,zhang yan-bing
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منبع
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food analytical methods - 2017 - دوره : 10 - شماره : 7 - صفحه:2185 -2193
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چکیده
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A multiresidue method has been optimized and validated for the rapid determination of 12 veterinary drugs belonging to β-agonists and β-lactam antibiotics in porcine muscle. it has been based on liquid chromatography-tandem mass spectrometry and a simple extraction procedure using acetonitrile/h2o. the extract was centrifuged, and the supernatant was directly analyzed by lc-ms/ms in positive ion mode with multiple reaction monitoring (mrm). the linearity of each analyte was almost the coefficient of determination (r) > 0.99. mean recoveries for all analytes ranged from 74.6 to 115.3% with intra-day rsd ≤ 17.2% and inter-day rsd ≤18.1%. limits of detection (lods) and limits of quantification (loqs) ranged from 0.4 to 2.0 and 1.0 to 8.0 ng/g, respectively. finally, the validated method was successfully applied to the quantitative analysis of real samples, and clorprenaline was detected in one out of 15 pork samples.
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کلیدواژه
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multiresidue analysis ,veterinary drug ,lc-ms/ms ,porcine muscle ,β-lactam antibiotics ,β-agonists
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آدرس
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zhengzhou university, school of pharmaceutical sciences, institute of drug discovery & development., china. collaborative innovation center of new drug research and safety evaluation, china, zhengzhou university, school of pharmaceutical sciences, institute of drug discovery & development., china, zhengzhou university, school of pharmaceutical sciences, institute of drug discovery & development., china, zhengzhou university, school of pharmaceutical sciences, institute of drug discovery & development., china, zhengzhou university, school of pharmaceutical sciences, institute of drug discovery & development., china, zhengzhou university, school of pharmaceutical sciences, institute of drug discovery & development., china. collaborative innovation center of new drug research and safety evaluation, china, zhengzhou university, school of pharmaceutical sciences, institute of drug discovery & development., china. collaborative innovation center of new drug research and safety evaluation, china
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Authors
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