combination of vortex-assisted liquid–liquid extraction and air-assisted liquid–liquid microextraction for the extraction of bisphenol a and bisphenol b in canned doogh samples

A sensitive, rapid, and efficient analytical method based on vortex-assisted liquid–liquid extraction combined with air-assisted liquid–liquid microextraction using high performance liquid chromatography-variable wavelength detection has been developed for the extraction and determination of bisphenol a and bisphenol b in canned doogh samples. in this method, the analytes are partitioned into n-hexane during liquid–liquid extraction and then they are enriched using the following air-assisted liquid–liquid microextraction procedure in a few microliters of an ammonia solution used as an extraction solvent. under the optimum conditions, limits of detection and quantification were 0.82 and 0.54 and 2.7 and 1.5 ng ml−1, for bisphenol a and bisphenol b, respectively. the extraction recoveries and enrichment factors of the selected analytes were 86 and 81% and 4300 and 4050, respectively. the relative standard deviations were lower than 9% for intra- (n = 6) and inter-day (n = 4) precisions at a concentration of 5 ng ml−1 of each analyte. finally, some canned doogh samples were effectively analyzed by the proposed method.