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Repeated stressors in adulthood increase the rate of biological ageing
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نویسنده
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hau m. ,haussmann m.f. ,greives t.j. ,matlack c. ,costantini d. ,quetting m. ,adelman j.s. ,miranda a.c. ,partecke j.
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منبع
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frontiers in zoology - 2015 - دوره : 12 - شماره : 1
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چکیده
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Background: individuals of the same age can differ substantially in the degree to which they have accumulated tissue damage,akin to bodily wear and tear,from past experiences. this accumulated tissue damage reflects the individual's biological age and may better predict physiological and behavioural performance than the individual's chronological age. however,at present it remains unclear how to reliably assess biological age in individual wild vertebrates. methods: we exposed hand-raised adult eurasian blackbirds (turdus merula) to a combination of repeated immune and disturbance stressors for over one year to determine the effects of chronic stress on potential biomarkers of biological ageing including telomere shortening,oxidative stress load,and glucocorticoid hormones. we also assessed general measures of individual condition including body mass and locomotor activity. results: by the end of the experiment,stress-exposed birds showed greater decreases in telomere lengths. stress-exposed birds also maintained higher circulating levels of oxidative damage compared with control birds. other potential biomarkers such as concentrations of antioxidants and glucocorticoid hormone traits showed greater resilience and did not differ significantly between treatment groups. conclusions: the current data demonstrate that repeated exposure to experimental stressors affects the rate of biological ageing in adult eurasian blackbirds. both telomeres and oxidative damage were affected by repeated stress exposure and thus can serve as blood-derived biomarkers of biological ageing. © 2015 hau et al.; licensee biomed central.
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کلیدواژه
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Biomarker; Eurasian blackbird; Glucocorticoid; Oxidative stress; Repeated stressors; Telomere
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آدرس
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evolutionary physiology group,max planck institute for ornithology,am obstberg 1,radolfzell,78315,germany,university of konstanz,department of biology,universitätsstraße 10,konstanz,78464, Germany, bucknell university,department of biology,lewisburg,pa 17837, United States, evolutionary physiology group,max planck institute for ornithology,am obstberg 1,radolfzell,78315,germany,north dakota state university,department of biological sciences,1340 bolley drive,fargo,nd 58202, United States, bucknell university,department of biology,lewisburg,pa 17837, United States, university of antwerp,department of biology,universiteitsplein 1,wilrijk,2610,belgium,institute of biodiversity,animal health and comparative medicine,university of glasgow,glasgow,qg12 8q, United Kingdom, evolutionary physiology group,max planck institute for ornithology,am obstberg 1,radolfzell,78315,germany,university of konstanz,department of biology,universitätsstraße 10,konstanz,78464, Germany, evolutionary physiology group,max planck institute for ornithology,am obstberg 1,radolfzell,78315,germany,department of biological sciences,4092b derring hall,virginia tech,blacksburg,va 24061-0406, United States, university of konstanz,department of biology,universitätsstraße 10,konstanz,78464,germany,max planck institute for ornithology,department of migration and immuno-ecology,am obstberg 1,radolfzell,78315,germany,universidade federal do maranhão,campus do bacanga,departamento de biologia,centro de ciências biológicas e da saúde,são luís,maranhão, Brazil, university of konstanz,department of biology,universitätsstraße 10,konstanz,78464,germany,max planck institute for ornithology,department of migration and immuno-ecology,am obstberg 1,radolfzell,78315, Germany
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