|
|
|
|
Interaction effects of BDNF and COMT genes on resting-state brain activity and working memory
|
|
|
|
|
|
|
|
نویسنده
|
chen w. ,chen c. ,xia m. ,wu k. ,chen c. ,he q. ,xue g. ,wang w. ,he y. ,dong q.
|
|
منبع
|
frontiers in human neuroscience - 2016 - دوره : 10 - شماره : NOV2016
|
|
چکیده
|
Catechol-o-methyltransferase (comt) and brain-derived neurotrophic factor (bdnf) genes have been found to interactively influence working memory (wm) as well as brain activation during wm tasks. however,whether the two genes have interactive effects on resting-state activities of the brain and whether these spontaneous activations correlate with wm are still unknown. this study included behavioral data from wm tasks and genetic data (comt rs4680 and bdnf val66met) from 417 healthy chinese adults and resting-state fmri data from 298 of them. significant interactive effects of bdnf and comt were found for wm performance as well as for resting-state regional homogeneity (reho) in wm-related brain areas,including the left medial frontal gyrus (lmefg),left superior frontal gyrus (lsfg),right superior and medial frontal gyrus (rsmfg),right medial orbitofrontal gyrus (rmofg),right middle frontal gyrus (rmfg),precuneus,bilateral superior temporal gyrus,left superior occipital gyrus,right middle occipital gyrus,and right inferior parietal lobule. simple effects analyses showed that compared to other genotypes,subjects with comt-vv/bdnf-vv had higher wm and lower reho in all five frontal brain areas. the results supported the hypothesis that comt and bdnf polymorphisms influence wm performance and spontaneous brain activity (i.e.,reho). © 2016 chen,chen,xia,wu,chen,he,xue,wang,he and dong.
|
|
کلیدواژه
|
BDNF; COMT; Interaction effect; Regional homogeneity; Working memory
|
|
آدرس
|
state key laboratory of cognitive neuroscience,learning and idg/mcgovern institute for brain research,beijing normal university,beijing,china,center for collaboration and innovation in brain and learning sciences,beijing normal university,beijing, China, state key laboratory of cognitive neuroscience,learning and idg/mcgovern institute for brain research,beijing normal university,beijing,china,center for collaboration and innovation in brain and learning sciences,beijing normal university,beijing, China, state key laboratory of cognitive neuroscience,learning and idg/mcgovern institute for brain research,beijing normal university,beijing,china,center for collaboration and innovation in brain and learning sciences,beijing normal university,beijing, China, department of psychology and social behavior,university of california,irvine,ca, United States, department of psychology and social behavior,university of california,irvine,ca, United States, faculty of psychology,southwest university,chongqing, China, state key laboratory of cognitive neuroscience,learning and idg/mcgovern institute for brain research,beijing normal university,beijing,china,center for collaboration and innovation in brain and learning sciences,beijing normal university,beijing, China, state key laboratory of cognitive neuroscience,learning and idg/mcgovern institute for brain research,beijing normal university,beijing,china,center for collaboration and innovation in brain and learning sciences,beijing normal university,beijing, China, state key laboratory of cognitive neuroscience,learning and idg/mcgovern institute for brain research,beijing normal university,beijing,china,center for collaboration and innovation in brain and learning sciences,beijing normal university,beijing, China, state key laboratory of cognitive neuroscience,learning and idg/mcgovern institute for brain research,beijing normal university,beijing,china,center for collaboration and innovation in brain and learning sciences,beijing normal university,beijing, China
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|