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Aberrant functional connectivity between the amygdala and the temporal pole in drug-free generalized anxiety disorder
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نویسنده
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li w. ,cui h. ,zhu z. ,kong l. ,guo q. ,zhu y. ,hu q. ,zhang l. ,li h. ,li q. ,jiang j. ,meyers j. ,li j. ,wang j. ,yang z. ,li c.
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منبع
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frontiers in human neuroscience - 2016 - دوره : 10 - شماره : NOV2016
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چکیده
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The amygdala and the dorsolateral prefrontal cortex (dlpfc) play important roles in “emotion dysregulation,” which has a profound impact on etiologic research of generalized anxiety disorder (gad). the present study analyzed both eyes-open and eyes-closed resting state functional mri (rs-fmri) of 43 subjects (21 gad patients with medicine free and 22 matched healthy controls). the amygdala and the dlpfc were defined as regions of interest (roi) to analyze functional connectivity (fc) in gadpatients compared with healthy controls. the main findings revealed gad patients had increased fc between the amygdala and the temporal pole compared to healthy controls,which was found in both eyes-open and eyes-closed rs-fmri. and altered fcbetween the rois and brain regions that mainly belonged to the default mode network (dmn) were found. these findings suggest that the abnormal fc between the amygdala and the temporal pole may contribute to the pathophysiology of gad,and provide insights into the current understanding of the emotion dysregulation of anxiety disorders. © 2016 li,cui,zhu,kong,guo,zhu,hu,zhang,li,li,jiang,meyers,li,wang,yang and li.
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کلیدواژه
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Amygdala; DLPFC; DMN; Functional connectivity; Generalized anxiety disorder; Temporal pole
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آدرس
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shanghai key laboratory of psychotic disorders,shanghai mental health center,shanghai jiao tong university school of medicine,shanghai, China, shanghai key laboratory of psychotic disorders,shanghai mental health center,shanghai jiao tong university school of medicine,shanghai, China, shanghai key laboratory of psychotic disorders,shanghai mental health center,shanghai jiao tong university school of medicine,shanghai, China, college of education,shanghai normal university,shanghai, China, shanghai key laboratory of psychotic disorders,shanghai mental health center,shanghai jiao tong university school of medicine,shanghai, China, shanghai key laboratory of psychotic disorders,shanghai mental health center,shanghai jiao tong university school of medicine,shanghai, China, department of psychology,qiqihar mental health center,qiqihar, China, guangji hospital of suzhou,suzhou, China, shanghai key laboratory of psychotic disorders,shanghai mental health center,shanghai jiao tong university school of medicine,shanghai, China, department of psychiatry,tongji hospital of tongji university,shanghai, China, shanghai key laboratory of psychotic disorders,shanghai mental health center,shanghai jiao tong university school of medicine,shanghai, China, nathan s. kline institute for psychiatric research,new york,ny, United States, shanghai key laboratory of magnetic resonance,department of physics,east china normal university,shanghai, China, shanghai key laboratory of psychotic disorders,shanghai mental health center,shanghai jiao tong university school of medicine,shanghai,china,key laboratory for the genetics of developmental and neuropsychiatric disorders,bio-x institutes,ministry of education,shanghai jiao tong university,shanghai,china,brain science and technology research center,shanghai jiao tong university,shanghai, China, cas key laboratory of behavioral science,mri research center,institute of psychology,chinese academy of sciences,beijing, China, shanghai key laboratory of psychotic disorders,shanghai mental health center,shanghai jiao tong university school of medicine,shanghai,china,key laboratory for the genetics of developmental and neuropsychiatric disorders,bio-x institutes,ministry of education,shanghai jiao tong university,shanghai,china,brain science and technology research center,shanghai jiao tong university,shanghai, China
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Authors
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