|
|
|
|
Cognitive processing in non-communicative patients: What can event-related potentials tell us?
|
|
|
|
|
|
|
|
نویسنده
|
lugo z.r. ,quitadamo l.r. ,bianchi l. ,pellas f. ,veser s. ,lesenfants d. ,real r.g.l. ,herbert c. ,guger c. ,kotchoubey b. ,mattia d. ,kübler a. ,laureys s. ,noirhomme q.
|
|
منبع
|
frontiers in human neuroscience - 2016 - دوره : 10 - شماره : NOV2016
|
|
چکیده
|
Event-related potentials (erp) have been proposed to improve the differential diagnosis of non-responsive patients. we investigated the potential of the p300 as a reliable marker of conscious processing in patients with locked-in syndrome (lis). eleven chronic lis patients and 10 healthy subjects (hs) listened to a complex-tone auditory oddball paradigm,first in a passive condition (listen to the sounds) and then in an active condition (counting the deviant tones). seven out of nine hs displayed a p300 waveform in the passive condition and all in the active condition. hs showed statistically significant changes in peak and area amplitude between conditions. three out of seven lis patients showed the p3 waveform in the passive condition and five of seven in the active condition. no changes in peak amplitude and only a significant difference at one electrode in area amplitude were observed in this group between conditions. we conclude that,in spite of keeping full consciousness and intact or nearly intact cortical functions,compared to hs,lis patients present less reliable results when testing with erp,specifically in the passive condition. we thus strongly recommend applying erp paradigms in an active condition when evaluating consciousness in non-responsive patients. © 2016 lugo,quitadamo,bianchi,pellas,veser,lesenfants,real,herbert,guger,kotchoubey,mattia,kübler,laureys and noirhomme.
|
|
کلیدواژه
|
Event-related potentials; Locked-in syndrome; Minimally conscious state; P300; Unresponsive wakefulness syndrome; Vegetative state
|
|
آدرس
|
coma science group,university and university hospital of liège,giga,liège,belgium,institute of psychology,university of würzburg,würzburg,germany,french association of locked-in syndrome (alis),paris, France, neuroelectrical imaging and bci laboratory,fondazione santa lucia,irccs,rome,italy,school of life and health sciences,aston brain centre,aston university,birmingham, United Kingdom, department of civil engineering and computer science,university of rome tor vergata,rome, Italy, french association of locked-in syndrome (alis),paris,france,coma arousal unit-pmr department,nîmes university hospital,nîmes, France, institute for medical psychology and behavioural neurobiology,university of tübingen,tübingen, Germany, coma science group,university and university hospital of liège,giga,liège, Belgium, institute of psychology,university of würzburg,würzburg, Germany, institute of psychology,university of würzburg,würzburg,germany,department of psychiatry,university of tübingen,tübingen,germany,department of biomedical resonance,university of tübingen,tübingen, Germany, g.tec medical engineering gmbh/guger technologies og,graz, Austria, institute for medical psychology and behavioural neurobiology,university of tübingen,tübingen, Germany, neuroelectrical imaging and bci laboratory,fondazione santa lucia,irccs,rome, Italy, institute of psychology,university of würzburg,würzburg, Germany, coma science group,university and university hospital of liège,giga,liège, Belgium, coma science group,university and university hospital of liège,giga,liège,belgium,department of cognitive neuroscience,maastricht university,maastricht,netherlands,brain innovation b.v,maastricht, Netherlands
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|