Feasibility the Biological Monitoring of Workers Exposed to Benzene and Toluene via Measuring the Parent Compounds in the Exhaled Breath

Background: solvents such as benzene and toluene are commonly used in tire manufacturing, and significant occupational exposure to these chemicals adversely affects the health of workers. in biological monitoring, a complementary method for personal monitoring, the internal absorbed dose is measured and individual, environmental, and exposure differences are taken into consideration. objectives: the present study evaluated external doses by personal monitoring and investigated a more practical approach to biological monitoring by measuring the internal doses of benzene and toluene in workers involved in tire manufacturing. materials and methods: personal monitoring of 100 workers in tire factories a and b (n = 50 samples from each factory, n = 100 total personal samples) was performed using the national institute for occupational safety and health 1501 method. biological monitoring of the workers was performed by collecting exhaled air in tedlar® bags (n = 100). personal and biological samples were analyzed by a gas chromatograph equipped with a flame ionization detector. data were analyzed by independent t-test and correlation coefficients. results: there were no significant differences between factories with respect to worker age or work history. personal exposure to benzene exceeded the current threshold limit value in 68% of workers. occupational exposure to benzene and toluene as external (i.e. in the breathing area) and internal doses (i.e. in the exhaled air) were significantly higher in factory b than factory a. in addition, the external and internal doses of both compounds were significantly correlated. conclusions: the workplace conditions of tire factories must be improved. the biological exposure index can be calculated by determining the unchanged benzene and toluene concentrations in exhaled air; this can be used as a more reliable method for personal monitoring.