Association Between A561C Polymorphism of E-Selectin Gene and Coronary Arterial Disease in Southeastern Iranian Population

Background: numerous factors including genetic factors play a role in pathogenesis of coronary atherosclerosis. it has been reported that polymorphisms of genes encoding adhesion molecules are associated with atherosclerosis. objectives: the present research aimed to evaluate a561c polymorphism of the e-selectin gene in patients with coronary arterial diseases (cad). materials and methods: eighty seven cad patients and 93 age- and sex-matched control subjects were enrolled in this research. the polymorphism of a561c in the e-selectin gene was defined by polymerase chain reaction followed by restriction fragment length polymorphism (pcr-rflp). results: the prevalence’s of aa, ac and cc genotypes were 55.2%, 24.1% and 20.7% in cad patients and 51.6%, 40.9% and 7.5% in the control subjects, respectively. the frequencies of the c allele were significantly higher in cad patients compared with control groups (p < 0.05). logistic regression analysis revealed a significant association between the c allele and the risk of cad (or = 1.61, 95%ci = 1.03-2.51). conclusions: our results displayed that presence of c allele at position 561 e-selection gene is associated with increased risk of atherosclerosis disease in the southeastern iranian population. this polymorphism may be able to affect leukocyte-endothelial interactions, which may account for the pathogenesis of atherosclerosis.