Association Between Betaine Homocysteine S-Methyl Transferase (BHMT) rs3797546 Gene Polymorphisms and the Risk of Nonsyndromic Cleft Lip and/or Cleft Palate in South-East Population of Iran

Background: nonsyndromic cleft lip with or without cleft palate (ns-cl/p) is one of the most common congenital anomalies and has a multifactorial etiology that involves both genetic and environmental factors. objectives: the present study was aimed to evaluate the possible association between bhmt rs3797546 gene polymorphisms and ns-cl/p in a sample of iranian population. materials and methods: this case-control study was performed on 100 ns-cl/p cases and 100 healthy controls. tetra amplification refractory mutation system-polymerase chain reaction (t-arms-pcr) was used to detect the polymorphism. analysis of data was done using χ2 test for categorical data, the associations between genotypes and ns-cl/p were estimated by computing the odds ratio (or) and 95% confidence intervals (95% ci) from logistic regression analyses. results: no significant difference was found between the groups regarding bmht rs3797546 gene polymorphism. the c allele was not associated with ns-cl/p (or = 1.27, 95% ci = 0.85-2.79, p = 0.690). conclusions: our data suggested that bmht rs3797546 gene polymorphism was not associated with risk/ protection for ns-cl/p in a sample of iranian population. larger studies are required to validate our findings.