Aloe vera Aqueous Extract Effect on Morphine Withdrawal Syndrome in Morphine-Dependent Female Rats

Background: aloe vera is a medicinal herb used as an anti-inflammatory and sedative agent.objectives: the current study aimed to evaluate the effect of aloe vera aqueous extract on morphine withdrawal symptoms in morphine-dependent female rats.patients and methods: the current research was performed on 40 female wista-albino rats which were made dependent on morphine using houshyar protocol and were randomly divided into five groups (a, b, c, d, and e). group a did not receive any agent in the period of handling but other groups (b, c, d and e) received 5, 10, 20 and 40 mg/kg of aloe vera aqueous extract by gavage, three times daily for a week, respectively. withdrawal symptoms, stool form, agitation, disparity, floppy eyelids, and body mass variations were checked for 10 days. the obtained data were analyzed using spss v.11 software, and friedman, kruskal-wallis, and mann-whitney statistical tests. statistical difference was considered significant (p < 0.05).results: the results of the present study showed that agitation, disparity, and floppy eyelids in group e were significantly higher than those of others groups; however, these symptoms in group c were significantly lower than those of the other groups.conclusions: the results of the present study revealed that the aloe vera aqueous extract had various effects on morphine withdrawal syndrome in morphine-dependent female rats .