serum fetuin-a and adipsin levels in type ii diabetes patients

Background: fetuin-a is a glycoprotein known as a biomarker for diabetes risk. adipsin or complement factor d (cfd) plays a role in glucose tolerance, and metabolism. objectives: this study aimed to investigate the concentration of fetuin-a and adipsin in patients with type 2 diabetes mellitus (t2dm) and healthy subjects. patients and methods: this case–control study was carried out on 43 patients with t2dm and 41 healthy subjects. biochemical parameters were determined. fetuin-a and adipsin levels were measured using elisa kits. lipid profile and biochemical factors were measured by spectrophotometric methods. results: the results showed a trend toward lower fetuin-a and cfd concentrations between the two groups (p < 0.05). there was a significant correlation between the levels of fetuin- a and adipsin (p < 0.0001), fbs and hba1c (p = 0.02), fbs and creatinine (p = 0.03), and bun (p < 0.001).there was significant differences according to biochemical levels between the two groups (p < 0.001). conclusions: the findings suggest that fetuin-a and adipsin levels were decreased in t2dm. it seems that the result of fetuin-a and adipsin levels in the diabetes depends on numerous vague factors. nevertheless, in comparison with published data the changes of fetuin and adipsin levels in patients witht2dmindicate a complex but not complete role of fetuin-a and adipsin in the pathogenesis of t2dm.