detection of the o6-carboxymethylguanine dna adduct in colorectal cancer using a graphene field-effect transistor-based biosensors

Efforts to understand genetic diseases and mutations in biological systems are the most important driver of research development in medical and biomolecular sciences. rapid, sensitive, accurate, and cost-effective biomolecule analysis is particularly important in diagnosis and treatment. the discovery of graphene as a new nanomaterial with a carbon structure with a single atom thickness due to its unique electronic, mechanical, thermal, and optical properties has opened a new topic in research in various biomedical sciences and the production of biosensors for biomolecule analysis. in this research, a biosensor based on a graphene field-effect transistor (gfet) is used to detect dna with optimal accuracy and sensitivity, which can be a basis for making dna detection tools. in the studied structure, using non-equilibrium green function equations and poisson equation, we study the electron transfer in graphene field-effect transistors. then, by examining the interaction between nucleotide bases (c, g, a, t) and o6-carboxymethylguanine related to the colorectal cancer dna sequence to detection of mutation will be identified by gfet, and their binding energy determined.