hematologic and electrocardiographic findings in sub-acute experimental monensin toxicosis in goats

Toxic effects of monensin, a polyether antibiotic mainly used as coccidiostat, have been described in a wide range of animals. the present study aimed to investigate the hematologic and electrocardiographic features of sub-acute monensin toxicosis in goats. for this purpose, seven adult goats were administered sodium monensin, 13 mg/kg, daily for 5 consecutive days via gastric gavage. hematologic parameters including pcv, hemoglobin (hb), total white blood cell (wbc) and differential count, total protein of plasma (tpp) and fibrinogen, were determined in baseline and daily blood samples for 10 days. significant elevation of hb at day 1, wbc at day 7, neutrophils percent at days 5 and 8, lymphocytes percent at days 5, 8 and 9, monocytes percent at days 1 and 3, absolute numbers of monocytes at days 1, 3, 6 and tpp at day 1, were observed in monensin exposed goats. at electrocardiography, sinus tachycardia, sinus bradycardia, s-t segment depression, and ventricular premature complexes and ventricular tachycardia were the most prominent findings. these findings suggest that sub-acute monensin toxicosis in goats, alters some hematologic parameters and causes a numbers of electrocardiographic abnormalities related to toxic cardiomyopathy in exposed goats.

hematologic and electrocardiographic findings in sub-acute experimental monensin toxicosis in goats

toxic effects of monensin, a polyether antibiotic mainly used as coccidiostat, have been described in a wide range of animals. the present study aimed to investigate the hematologic and electrocardiographic features of sub-acute monensin toxicosis in goats. for this purpose, seven adult goats were administered sodium monensin, 13 mg/kg, daily for 5 consecutive days via gastric gavage. hematologic parameters including pcv, hemoglobin (hb), total white blood cell (wbc) and differential count, total protein of plasma (tpp) and fibrinogen, were determined in baseline and daily blood samples for 10 days. significant elevation of hb at day 1, wbc at day 7, neutrophils percent at days 5 and 8, lymphocytes percent at days 5, 8 and 9, monocytes percent at days 1 and 3, absolute numbers of monocytes at days 1, 3, 6 and tpp at day 1, were observed in monensin exposed goats. at electrocardiography, sinus tachycardia, sinus bradycardia, s-t segment depression, and ventricular premature complexes and ventricular tachycardia were the most prominent findings. these findings suggest that sub-acute monensin toxicosis in goats, alters some hematologic parameters and causes a numbers of electrocardiographic abnormalities related to toxic cardiomyopathy in exposed goats.