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recurrent pemphigus foliaceus in horse: a case report
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نویسنده
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sadeghi-nasab ali ,zolhavarieh massoud ,ashrafihelan javad ,sadeghi dehkordi zainab ,bahari aliasghar ,nourian alireza
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منبع
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دامپزشكي ايران - 2023 - دوره : 19 - شماره : 3 - صفحه:96 -101
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چکیده
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An 8-year-old crossbred thoroughbred chestnut stallion was suspected to an autoimmune mediated skin disease based on history, clinical observations, microbiological and clinicopathologically findings. the clinical signs disappeared completely after five weeks of treatment with po prednisolone. however, approximately eight months later, the lesions recurred in a more severe form. there was no improvement despite the repeating previous treatment by horse’s owner; therefore, oral azathioprine was added to prednisolone after skin biopsy. a significant therapeutic effect was observed by this combination, however; the use of azathioprine was discontinued after fifteen days due to diarrhea, while prednisolone continued for another week. after improvement of the symptoms, oral prednisolone was also stopped with a decreasing trend. vesiculobullous to pustular lesions with acantholytic characteristic of the stratum corneum and stratum granulosum of epidermis were the histopathological findings, characteristics of pemphigus foliaceus. this is the first reported case of recurrent pemphigus foliaceus in iran.
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کلیدواژه
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autoimmune ,histopathology ,relapse ,skin ,type ii hypersensitivity
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آدرس
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bu-ali sina university, faculty of veterinary sciences, department of clinical sciences, iran, bu-ali sina university, faculty of veterinary sciences, department of clinical sciences, iran, university of tabriz, faculty of veterinary medicine, department of pathobiology, iran, bu-ali sina university, faculty of veterinary sciences, department of pathobiology, iran, bu-ali sina university, faculty of veterinary sciences, department of clinical sciences, iran, bu-ali sina university, faculty of veterinary sciences, department of pathobiology, iran
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پست الکترونیکی
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nourian.ar@gmail.com
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recurrent pemphigus foliaceus in horse: a case report
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Authors
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Abstract
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an 8-year-old crossbred thoroughbred chestnut stallion was suspected to an autoimmune mediated skin disease based on history, clinical observations, microbiological and clinicopathologically findings. the clinical signs disappeared completely after five weeks of treatment with po prednisolone. however, approximately eight months later, the lesions recurred in a more severe form. there was no improvement despite the repeating previous treatment by horse’s owner; therefore, oral azathioprine was added to prednisolone after skin biopsy. a significant therapeutic effect was observed by this combination, however; the use of azathioprine was discontinued after fifteen days due to diarrhea, while prednisolone continued for another week. after improvement of the symptoms, oral prednisolone was also stopped with a decreasing trend. vesiculobullous to pustular lesions with acantholytic characteristic of the stratum corneum and stratum granulosum of epidermis were the histopathological findings, characteristics of pemphigus foliaceus. this is the first reported case of recurrent pemphigus foliaceus in iran.
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