An unusual presentation of mammary Paget’s disease with a 12-year duration and no palpable mass

Paget’s disease of the nipple is an unusual manifestation of breastcancer. most cases of mammary paget`s disease are associatedwith an invasive or in situ breast tumor, even with no massobserved in mammography imaging. very rarely does paget’sdisease occur in the absence of any underlying neoplasia .herein,we report an 82-year-old woman with an unusual presentationof mammary paget’s disease with a 12-year duration, and nopalpable mass, density or calcification in imaging assessments.immunohistochemistry showed that the tumor cells stainedpositive for cytokeratin-7, and her-2-neu, yet negative for s-100,hmb-45, cea, and p63. skin biopsy and immunohistochemistryfindings corresponded with paget’s disease.