Anticonvulsive drug (carbamazepine) induced toxic epidermal necrolysis and screening for HLA B1502

Epilepsy is a common neurological disorder that can be detected in any country. there are several anticonvulsive drugs. a widely used drug is carbamazepine. the present concern on this drug is its important common side effect, induction of toxic epidermal necrolysis (ten). for this side effect of carbamazepine, its pharmacogenomics and hla relationship have widely been studied. some recent reports show the relationship which is the origin of the new concept for screening for hla b1502. for screening, a lot of evidence (see pubmed) imply the advantage of screening 1-2.