interleukin-15 contributes to the benefits of βeta-alanine supplementation on the performance of elite volleyball players

Background: volleyball involves intermittent activities closely linked to explosive power and muscular strength. utilizing the ergogenic supplement beta-alanine can positively influence the balance between anabolic and catabolic factors, potentially enhancing the benefits of sports activities.objectives: this study aimed to examine the effect of 4 weeks of beta-alanine supplementation on serum myokine levels, as well as aerobic and anaerobic power in elite volleyball players aged 22 - 28 years. methods: in this quasi-experimental study, 22 male volleyball players from the division 1 volleyball league, aged between 22 and 28, were selected and randomly divided into two groups of 11: a supplement group and a control group. the supplement group received 6.4 g/day of beta-alanine (in 8 doses of 800 mg) for 4 weeks. the ancova test was used for data analysis, with a significance level set at p ≤ 0.05. results: beta-alanine supplementation significantly increased serum myokine levels (interleukin-15, myonectin, and irisin) compared to the control group (p < 0.05). additionally, 4 weeks of beta-alanine supplementation was associated with a significant increase in measures of aerobic and anaerobic power (bruce and wingate tests) compared to the control group (p < 0.05). conclusions: supplementation with beta-alanine led to improved performance (aerobic and anaerobic power) by increasing anabolic responses (irisin) and indicators of muscle hypertrophy (il-15 and myonectin) in elite volleyball players.