the effect of interval training on ptx3, vcam-1, and crp in rats with metabolic syndrome

Background: sedentary lifestyle and lack of exercise cause cardiovascular diseases and metabolic syndrome. decreased movement in recent decades has caused cardiovascular diseases. methods: in this research, 35 male wistar rats weighing 220 ± 20 g were divided into 5 groups (seven rats in each group) by a simple random method. the first and second experimental groups were given 100 grams per liter of fructose with water for 6 weeks, and the third experimental group received this for 14 weeks. the training group performed the interval training protocol on the treadmill for eight weeks and 5 days a week. one-way analysis of variance (anova) was used to compare the groups. results: the use of the fructose diet for 6 weeks and 14 weeks caused metabolic syndrome in male wistar rats. induction of metabolic syndrome increased the plasma levels of ptx3, vacm-1, and crp at the end of 6 weeks (p = 0.001, p = 0.018, and p = 0.004, respectively) and the fourteenth week (p = 0.001, p = 0.001, and p = 0.001, respectively). eight weeks of interval training significantly reduced ptx3, vacm-1, and crp (p = 0.034, p = 0.027 and p = 0.021, respectively). conclusions: the fructose diet caused metabolic syndrome and a significant increase in inflammatory markers in rats, and high-intensity interval training significantly reduced inflammatory factors in them.