Effects of Eight-Week Combined (Resistance and Endurance) Training on Serum Levels of Prostate Specific Antigen (PSA), Sex Hormone Binding Globulin (SHBG), and Phosphatase and Tensin Homolog (PTEN) in Men with Prostate Cancer

Background: prostate cancer (pc) is the second most prevalent cancer and the sixth cancer leading to death in men worldwide.objectives: the purpose of this study was to examine the effect of eight weeks of combined training on specific markers of prostatecancer in older adults.methods: twenty older adults (62±7 years) with prostate cancer were divided randomly into the control (n = 10) and training (n =10) groups. the training group performed exercise training in three sessions a week for eight weeks. resistance training includedtwo sets of 10 repetitions at 60 - 75% of one-repetition maximum, and endurance training contained treadmill running for 20 - 35minat 60 - 75% of maximumheart rate. bruce test, one-repetitionmaximum, and elisa technique were used respectively to measurethe aerobic performance, strength performance, and serum levels of prostate specific antigen (psa), sex hormone binding globulin(shbg), phosphatase and tensin homolog (pten), and testosterone (ts). a two-way analysis of variance with repeatedmeasures wasused to specify the differences.results: weight, fat percentage, body mass index (bmi), waist-hip ratio (whr), glucose, insulin, and psa were significantly lowerin the training group than the control group (p < 0.05). furthermore, strength performance, aerobic performance, shbg, ts, andpten were significantly higher in the training group than in the control group (p < 0.05).conclusions: combined training can have an influential role in physical condition improvement through decreasing the psaserum level and increasing shbg, ts, and peten serum levels, which helps patients with prostate cancer to be cured.