the relationship between serum resistin levels and diabetic nephropathy in type 2 diabetic patients

Background: resistin reduces tissue sensitivity to insulin and causes hyperglycemia. diabetic nephropathy is also a metabolic disorder caused by chronic hyperglycemia that causes kidney dysfunction.objectives: this study aimed to investigate the relationship between serum resistin and diabetic nephropathy in diabetic patients who referred to imam reza hospital in 2018 - 2019. methods: this case-control study recruited 30 diabetic patients with nephropathy, 29 non-nephropathy diabetic patients, and 30 healthy controls via convenience sampling. serumand24-hour urine samples were takenfromeach person. after the determination of the glomerular filtration rate, samples were tested in a laboratory. also, data were analyzed by spss software version 23, and p < 0.05 was considered significant. results: mean serum resistin was significantly different between the groups (f = 3.600, p = 0.032). tukey’s follow-up test showed that resistin was critically higher in the diabetic nephropathy group than in the control group and healthy controls. there was a weak inverse relationship between glomerular filtration rate and serum resistin level (r = -0.233, p = 0.031). conclusions: levels of resistin may rise in people with diabetes associated with nephropathy. it seems that serum resistin can be used as a biomarker to assess the severity of diabetes mellitus.