determination of h2o2 in human serum samples with novel electrochemical sensor based on v2o5/vo2 nanostructures

Background: highly selective and sensitive analysis of hydrogen peroxide (h2o2) has attracted considerable interest in the fields of clinical diagnostics, food industry, and environmental analysis.objectives: in the present study, an efficient electrochemical sensor, based on v2o5/vo2 nanostructures, was introduced for measuring hydrogen peroxide (h2o2) in human serum samples.methods: the characterization of the prepared v2o5/vo2 nanostructures was investigated by x-ray diffraction (xrd), fourier transform infrared (ft-ir) spectroscopy, scanning electron microscopy (sem), and energy dispersive x-ray spectroscopy (edx). a carbon paste electrode (cpe) modified with v2o5/vo2 was applied for the electrochemical detection of h2o2.results: the prepared sensor depicted a good linear range from 8 to 215 μm and a low detection limit of 5 μm. moreover, the modified electrode showed notable anti-interference property and high sensitivity toward h2o2 detection. the suggested method was also successfully applied for the determination of h2o2 in human serum samples.conclusions: the v2o5/vo2 embedded cpe offers good simplicity, sensitivity, and selectivity toward h2o2 determination. in addition, the suggested assay revealed good reproducibility and anti-interference property in the measuring of h2o2.