vitamin e supplementation reduces oxidative stress in the male wistar rats’ brain against polyvinyl chloride products

Background: polyvinyl chloride (pvc) exerts toxic effects via the formation of oxidative stress on the brain. antioxidants such as vitamin e (vit e) can affect free radicals. objectives: this study was conducted to decrease damage and oxidative stress against pvc products in rats’ brain by vitamin e. methods: in the current study, weused 24 male wistar rats in four groups (n = 6 rats per group) as the control, vit e, pvc, pvc plus vit e.we orally administered vitamin e and pvc for 40 days. then the rats were anesthetized and the brain was removed and transferred to a temperature of -70ºc in order to measure lipid peroxidation. results: our results revealed that oral administration of pvc decreased catalase and total antioxidant capacity levels, and increased malondialdehyde in pvc exposed rats. vitamin e improved spatial memories by enhancing neurogenesis in the brain. conclusions: exposure to pvc can produce oxidative stress enzymes and make brain damage. vitamin e, as an antioxidant, can decrease the toxic effects of pvc and protect the brain.