lipid lowering effects of nigella sativa and swimming training in streptozotocin induced diabetic rats

Background: diabetes is a chronic disease that causes disorders in blood lipids. objectives: the purpose of this study was to investigate the lipid lowering effects of hydroalcoholic extract of nigella sativa and swim training in streptozotocininduced diabetic rats. methods: a total of 32 diabetic rats were selected and randomly divided into four equalsize groups: (1) swim training, (2) nigella sativa, (3) swim training with nigella sativa, and (4) control. groups 2 and 3 received 100 mg/kg/day of nigella sativa extract in the peritoneum. groups 1 and 3 also swam in a swimming tank (five days per week for four weeks). after this period, blood samples were taken. for analysis of the findings, paired sample ttest and twoway anova were used (p ≤ 0.05). results: swim training and nigella sativa consumption had a significant effect in reducing cholesterol (cho), triglycerides (tg), very lowdensity lipoprotein (vldl), and lowdensity lipoprotein (ldl) (p ≤ 0.05); highdensity lipoprotein (hdl) increased significantly following swim training (p ≤ 0.05); nigella sativa and swim training had significant interactive effects in reducing cho, tg, vldl, and ldl, and in increasing hdl (p ≤ 0.05). conclusions: it seems that four weeks of nigella sativa consumption combined with swimming training has a more favourable fatreducing effect than nigella sativa consumption or swim training alone.