Evaluation of the Association between Oral Lichen Planus and Hypothyroidism: a Retrospective Comparative Study

Statement of the problem: oral lichen planus (olp) is an autoimmune mucocutaneous disease. there are some reports of thyroid diseases, especially hypothyroidism, to have association with olp in some studies. purpose: based on the controversial results of former studies in other populations about the association of hypothyroidism and olp, the current study aimed to evaluate this association in a sample of iranian population. materials and method: this retrospective comparative study evaluated 523 patients with olp referring to the oral and maxillofacial department of shiraz dental faculty as the test group and 523 age- and sex-matched patients as the control group. those participants with oral lichenoid reactions and other mucosal lesions were excluded. the odds ratio (or) with 95% confidence intervals (ci) for the association of olp and thyroid diseases were estimated by logistic regression adjusted for the matched age and sex. results: in the test group, 74% (n=387) and in the control group 73.8% of the patients were female (n=386). in the test group, 26% (n=136) and in the control group 26.2% of the samples were male (n=137). a total of 4% of the patients in the control group (n=21) and 6.7% in the case group (n=35) had a history of hypothyroidism. the reported or for association of thyroid disease and olp was 1.714 (ci=0.984-2.987). conclusion: the results of this study showed no significant association between hypothyroidism and olp in comparison with the age- and sex-matched control group.