Evaluation of Plasma Isoprostane in Patients With Oral Lichen Planus

Statement of the problems: lichen planus is a chronic inflammatory disease. free radicals and reactive oxygen species play important roles in pathogenesis of oral lichen planus (olp). isoprostanes show oxidative stress and are formed by free-radical mediated lipid peroxidation of arachidonic acid and cell membrane phospholipids. purpose: this study was conducted to evaluate the plasma level of 8-isoprostane in patients suffering from erosive and non-erosive forms of olp. materials and method: in this case-control study, 31 patients with olp and 30 control subjects were enrolled. plasma samples were obtained and the level of 8- isoprostane was measured with sandwich enzyme-linked immunosorbent assay (elisa) in both groups. the data were analyzed by using two-sample t-test, chi-square and anova tests. results: the results showed significant increase in the plasma level of 8-isoprostane in olp group compared with the control group. the results of independent t-test revealed no significant correlation between the plasma level of isoprostane and sex, smoking, or previous treatment. conclusion: based on the findings of this study, oxidative stress was increased in patients with olp, reflected by higher concentrations of 8-isoprostane in plasma.