inflammatory status of excavated pulp tissue and internal root resorption in pulpotomized primary molars

Statement of the problem: internal root resorption after pulpotomy is a pathological phenomenon and can lead to early root resorption and subsequent loss of the tooth. purpose: to assess the relationship between initial inflammatory coronal pulp status in decayed primary molars treated by pulpotomy and internal root resorption after one-year follow-up. materials and method: in this clinical in vivo and in vitro experiment, vital pulpotomies were performed on 50 primary molars from 50 patients aged 5 to 10 years. coronal pulp was carefully removed followed by hemostasis and placement of a reinforced zinc oxide eugenol over the vital radicular pulp. enzyme-linked immunosorbent assay (elisa) assay was done on coronal pulp samples and the level of tumor necrosis factor-alpha (tnf- α) and interlukin-6 (il-6) was measured. after a 12-month follow-up, periapical radiographs were taken from pulpotomized teeth. kolmogorov-smirnov, chi-square, kruskal–wallis, and mann-whitney tests were implemented. results: 11 treated teeth (22%) showed an internal root resorption as diagnosed on x-rays. no significant association was found between tnf- α, il-6 levels, and pathological root resorption respectively (p= 0.953) and (p= 0.944). a significant association between age and pathological root resorption was observed (p= 0.031). no significant association be-tween remaining dentin thickness and pathological root resorption was established (p= 0.346). conclusion: there was no association between pro-inflammatory cytokines levels/ tnf- α, il-6 and internal root resorption following pulpotomy in pediatric patients.