association of il-17a polymorphism with chronic periodontitis in type 1 diabetic patients

Statement of the problem: the association of genetic polymorphisms with periodontitis has been studied extensively. the interleukin -17 (il-17) is a group of cytokines, which comprises six different molecules (il-17a, b, c, d, e & f). among these, il-17a & f are the most commonly understood cytokine, which plays a critical role in inflammatory diseases and peri-odontal inflammation. purpose: to evaluate whether il-17a gene polymorphism is associated with increased risk of chronic periodontitis in type 1 diabetes patients. materials and method: this quantitative case- control study was carried out in 60 subjects in 4 groups. the study groups included group a: 15 type 1 diabetes patients (t1dm) with chron-ic periodontitis (cp), group b: 15 t1dm patients without cp, group c: 15 non- diabetic pa-tients with cp, group d: 15 non-diabetic patients without cp. blood samples were drawn from the subjects and analyzed for il-17a polymorphism by using the polymerase chain reaction-restriction fragment length polymorphism method. results: there was no statistical significant difference seen in the genotype distribution among cp patients with or without t1dm and healthy controls. odds ratio and p value indi-cated that increased risks for cp were associated with il-17a allele (g) in patients with t1dm. this allele was correlated with worse clinical parameters of cp in t1dm patients. conclusion: the present study revealed that il-17a (rs2275913) polymorphism was not associated with increased risk for cp in t1dm patients.