Arg753gln and Arg677 Trp Polymorphisms of Toll-Like Receptor 2 in Acute Apical Abscess

Statement of the problem: genetic polymorphisms can alter immunity response against pathogens, which in turn influence individuals’ susceptibility to certain infec-tions. purpose: our aim was to determine the association of arg753gln (rs5743708) and arg677trp (rs12191786) polymorphisms of toll like receptor-2 gene with the two clinical forms of apical periodontitis: acute apical abscess (aaa) and asymptomatic apical periodontitis (aap). materials and method: there were 50 patients with aaa as case group and 50 with aap as control group. genotyping was done using tetra - arms (amplification re-fractory mutation system) pcr. results: heterozygous genotype of arg677trp polymorphism was associated with risk of aaa (or=1.9, 95% ci: 0.7-5.5, p= 0.05). although statistically insignificant, arg677trp polymorphism promoted the risk of aaa in dominant model (or=2.1, 95% ci: 0.7-5.9, p> 0.05). the frequency of mutant allele (t) of arg677trp poly -morphism was higher in aaa (14%) than aap (7%) subjects (or=1.7, 95% ci: 0.6-4.7). for arg753gln polymorphism, wild homozygous (gg) represented the domi-nant genotype in both cases (96%) and controls (100%). variant allele (a) of arg753gln polymorphism was identified in 2% of aaa, while no individual repre-sented with this allele in aap subjects. individuals with arg753gln; arg677trp (gg; tc) combination showed an elevated risk of aaa (or=1.6, 95% ci: 0.5- 4.2, p> 0.05). conclusion: arg677trp polymorphism of tlr-2 rendered a higher risk for the de- velopment of abscesses in apical periodontitis. it is recommended to explore role of this polymorphism in other populations.