evaluation of suppressor of cytokine signaling 1, interleukin-29 and lysosomal trafficking regulator in severe covid-19

Background: the pathogenesis of severe sars-cov-2 is closely linked to severe immune responses and inflammation caused by the sars-cov-2 virus. in this context, the suppressor of cytokine signaling 1 (socs1) has a crucial role in inhibiting cytokine-induced immune responses. on the other hand, interleukin-29 (il-29) and lysosomal trafficking regulator (lyst) are important molecules involved in inducing immune responses. objectives: this study aimed to assess the mrna levels of socs1, il-29, and lyst in the sars-cov-2-infected patients with severe symptoms. methods: in this cross-sectional study, 70 sars-cov-2 infected patients with severe symptoms and 70 healthy controls were evaluated. rna was extracted from peripheral blood and after cdna synthesis, the mrna levels of socs1, il-29, and lyst were assessed by real-time pcr technique.results: the study revealed that severe covid-19 patients exhibited a significant increase in mrna levels of il-29 compared to healthy individuals. however, there were no observed alterations in the mrna levels of socs1 and lyst in the patient group. conclusions: the results emphasize the importance of il-29 as a potential biomarker or therapeutic target for severe covid-19 cases. further research is needed to investigate the specific mechanisms through which il-29 influences immune responses and contributes to the development of severe disease. additionally, exploring other factors that may regulate socs1 and lyst expression could provide a more comprehensive understanding of their roles in covid-19 pathogenesis.