prevalence of vancomycin-resistant enterococcus spp. isolates in southeast iran, zahedan

Background: enterococci are clinically significant, especially in individuals with compromised immune systems, which are recognized as a critical contributor to nosocomial infections. objectives: this study aimed to determine antibiotic susceptibility profiles and vancomycin-resistance enterococcus (vre) isolates in zahedan, iran. methods: a hospital-based cross-sectional study was conducted at ali ibne abi talib hospital from march 2019 to february 2022. clinical samples included urine, blood, abscesses and other body fluids from patients referred to this hospital during the study period. a total of 3000 patients were included in the study, and the kirby-bauer method was used to test isolates identified by morphological and biochemical characteristics for antibiotic susceptibility. data were analyzed using spss software version 20. p-values < 0.05 were considered statistically significant. results: out of 3000 culture-positive clinical samples comprised of 82 urine, ten blood, one tracheal, two wound, and one pulmonary isolate, were identified as enterococcus faecalis(69.1%), enterococcus faecium(7.3%), and enterococcusspp. (23.6%). moreover, two-thirds of isolates were multidrug-resistant (mdr). although 66.7% and 63.9% were sensitive to nitrofurantoin and linezolid, resistance to ciprofloxacin (74.2%) and ampicillin (65.9%) was frequently observed. nitrofurantoin or linezolid were the only effective antibiotics for utis. in addition, 50% of isolates were resistant to vancomycin. conclusions: based on the results, a combination of vancomycin/or linezolid and nitrofurantoin for urine infections was effective against enterococci in this clinical center. nevertheless, continuous and frequent surveillance for resistance patterns is necessary for the reasonable and evidence-based use of antibiotics.