Investigation of Clinical Significant Utility of LncRNA-LINC02389 inPatients with Esophageal Squamous Cell Carcinoma

Background: the lncrna-linc02389 gene is a long non-coding rna, which has not been an assessed potential role in thepathogenesis of esophageal squamous cell carcinoma (escc).objectives: the purpose of the present survey was to evaluate the lncrna-linc02389 gene expression variation in subjects with escc.methods: the present survey was a preliminary investigation performed on seventy-five paired paraffin blocks including tumorousand non-tumorous marginal tissues from subjects with escc. after extraction of totalrnaandcdnasynthesis, the lncrna-linc02389gene expression change was evaluated using quantitative real-time pcr method.results: our data declared that the lncrna-linc02389 gene was significantly down-regulated in escc tissues compared to themarginal tissues (p< 0.05). in addition, the findingsshoweda significant association betweenthe lncrna-linc02389 gene expressionchange and tumor differentiation grade (p = 0.003).conclusions: our results proposed a possible carcinogenesis character of the lncrna-linc02389 gene and may be employed as aprognostic clinical significance in the progression of escc.