The Effects of Transcranial Direct Current Stimulation Overthe Dorsolateral Prefrontal Cortex on Cognitive Dysfunction inAlzheimer’s Disease: A Narrative Review

Context: patients with mild cognitive impairment (mci) and alzheimer’s disease (ad) are more likely to suffer from cognitivedysfunction due to dementia. transcranial direct current stimulation (tdcs) as a non-invasive treatment strategy has been usedas an efficient strategy to improve cognitive function.evidence acquisition: several studies investigating tdcs over the dorsolateral prefrontal cortex (dlpfc) were reviewed.results: most of these studies have targeted the left dlpfc, indicating that tdcs over the dlpfc can improve cognitive function,such as memory, visual recognition, attention, decision-making, and cognitive decline. however, there are still many unansweredquestions about the effect of tdcs over the dlpfc on the connectivity of this brain region as a key node for cognitive function.meanwhile, further research should be conducted to elucidate the effects of tdcs over the dlpfc on brain connectivity and adbiomarkers. in addition, more investigations should be conducted to identify the exact mechanisms affecting dlpfc stimulationon cognitive dysfunction in ad patients.conclusions: based on the results, tdcs over the dlpfc could improve cognitive function in ad patients.