evaluating the anticancer effects of polyvinyl alcohol/magnesium oxide bionanocomposite on human oral cancer cells

Background: oral squamous cell carcinoma (oscc) represents the most widespread type of squamous cell carcinoma (scc) in the head and neck region, comprising 90% of all cases of oral cancer. treatments based on immunological methods, cell therapy, gene therapy, and nanotechnology-based methods have been performed in addition to conventional treatment methods. objectives: this study aimed to investigate the anticancer effects of polyvinyl alcohol/mgo nanocomposite on human oral cancer cells. methods: in this study, the structure and size of nanoparticles and nanocomposite were identified using scanning electron microscope (sem) analysis after synthesizing pva/mgo nanocomposite. the anticancer activity of the synthesized nanocomposite was investigated against oral cancer cells of kb type. results: sem analysis confirmed the proper synthesis of pva/mgo nanocomposite. mtt test showed that the nanocomposite synthesized in the concentration range of 25-200μl has maximum anticancer properties against kb cancer cells. in addition, pva/mgo nanocomposite influenced the apoptosis pathway of kb cancer cells by increasing ros, decreasing mitochondrial membrane potential, and increasing the activities of caspases 3 and 7. conclusions: based on the results, the pva/mgo nanocomposite showed considerable potential as a viable contender for novel anticancer interventions.