antibiotic resistance in staphylococcus aureus in patients hospitalized in imam reza hospital of kermanshah, iran (2016 - 2018)

Background: staphylococcus aureus is an opportunistic pathogen, which often causes asymptomatic diseases. this bacterium could cause several disorders, ranging from skin infections to life-threatening diseases. s. aureus could also develop resistance to a wide range of antibiotics. objectives: the present study aimed to investigate the prevalence and pattern of antibiotic resistance in isolated s. aureus in imam reza hospital of kermanshah, iran. methods: this descriptive cross-sectional study was conducted on 2,228 patients with a positive s. aureus culturewhowere admitted to imam reza hospital during 2016 - 2018. in accordance with the clsi protocol, bacterial isolates were separated using laboratory tests, and antibiotic susceptibility was assessed using the standard disk-diffusion method. data analysis was performed in spss version 24. results: most of the s. aureus-positive cases were isolated from the emergency ward (43.7%), blood samples (40.1%), and urine samples (23.9%). the highest antibiotic resistancewasobserved against erythromycin, penicillin g, ofloxacin, cefoxitin, clindamycin, and piperacillin. with 93.3% and 81.8% sensitivity, vancomycin and teicoplanin were respectively the most effective antibiotics against s. aureus. conclusions: according to the results, the prevalence of resistant s. aureus strains could be due to the long-term hospitalization of patients and the overuse of antibiotics in infection treatment. therefore, proper monitoring and development of effective infection control methods are essential in these healthcare settings.