the association of the tnf-α-308g/a gene with recurrent miscarriage abortions in east azarbaijan

Background: recurrent pregnancy loss (rpl) is defined as two or more pregnancy losses before 20 weeks gestation. -tnf-α is a pro- inflammatory cytokine that has been proposed a candidate gene for the pathogenesis of rpl. this study aimed to investigate the association of tnf-α-308g/a polymorphism with rpl among east azarbaijan population. methods: the patient group comprised 100 women with the experience of three pregnancy losses and the control group comprised 100 women without any previous history of pregnancy loss. genotype tnf-α-308g/a was detected using pcr-rflp assay. results: the observed frequencies of gg and ga genotypes of tnf-α-308g/a polymorphism were respectively 84% and 16% in the patient group and 81% and 19% in the control group. aa genotype was not observed in any of the groups. conclusions: our results suggest that the tnf-α-308g/a polymorphism is not associated with rpl in east azarbaijan women.