Sebaceous hyperplasia: Systemic treatment with isotretinoin

The study aimed to verify the therapeutic action of isotretinoin in the treatment of sebaceous hyperplasia. during two months,20 patients with sebaceous hyperplasia took isotretinoin at a dosage of 1mg/kg per day. their skin lesions were counted and photographed before and after treatment and re-evaluated two years later. the average number of sebaceous hyperplasia lesions before treatment was 24 per patient. at the end of two months of therapy,the number of lesions decreased to 2 per patient. the statistically analyzed data showed a reduction in the number of lesions following isotretinoin use (p < 0.05). two years after the end of the treatment,the average number of sebaceous hyperplasia lesions was 4 per patient. there were no severe side effects. thus,the data analysis suggests that isotretinoin is a safe and effective drug for treating the disease under study. © 2015 by anais brasileiros de dermatologia.