Serious stomatitis and esophagitis: A peculiar mucous reaction induced by pegylated liposomal doxorubicin

Pegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. it has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. it rarely causes side-effects like cardiotoxicity or hair loss,but frequently results in many kinds of mucocutaneous reactions,including palmar-plantar erythrodysesthesia,diffuse follicular rash,intertrigo-like eruption,new formation of melanotic macules,stomatitis and radiation recall dermatitis. we present a rare case of multiple myeloma who immediately developed serious stomatitis and esophatitis associated with minor palmar-plantar erythrodysesthesia after a single course of pegylated liposomal doxorubicin. © 2015 by anais brasileiros de dermatologia.