Multiple cutaneous melanomas associated with gastric and brain metastases

The occurrence of multiple primary melanomas in a single individual is rare. most commonly,malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. we report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. during clinical evaluation and staging,we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. we suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2a (cdkn2a) (ink4a) in such cases. we also emphasize the importance of clinical examination and dermoscopy of the entire tegument,even after a malignant melanocytic lesion is identified. © 2016 by anais brasileiros de dermatologia.