Acute generalized exanthematous pustulosis induced by hydroxychloroquine: A case with atypical clinical presentation

Acute generalized exanthematous pustulosis is a rare drug-induced eruption that is characterized by acute,nonfol-licular sterile pustules on an erythematous and edematous base. the most frequently implicated drugs are beta-lactam antibiotics. hydroxychloroquine has been widely used to treat dermatologic and rheumatologic diseases and has been reported as a rare cause of acute generalized exanthematous pustulosis. a 42-year-old female presented with pustular lesions on the skin surface with erythema,facial edema,and occasional atypical target-like lesions after 21 days of treatment with 200mg/ day hydroxychloroquine for rheumatoid arthritis,diagnosed one month previously. we report a case with acute generalized exanthematous pustulosis induced by hydroxychloroquine and treated with dapsone and systemic corticosteroid. © 2017 by anais brasileiros de dermatologia.