Identifying the incidence of rash,Stevens-Johnson syndrome and toxic epidermal necrolysis in patients taking lamotrigine: A systematic review of 122 randomized controlled trials

Lamotrigine is an antiepileptic drug used for the treatment of epilepsy,bipolar disorder and numerous off-label uses. the development of rash significantly affects its use. the most concerning of these adverse reactions is stevens-johnson syndrome/toxic epidermal necrolysis. we performed a systematic review of randomized controlled trials using lamotrigine as a monotherapy to quantify the incidence of cutaneous reactions,particularly stevens-johnson syndrome/toxic epidermal necrolysis. of a total of 4,364 papers regarding lamotrigine,122 studies met our inclusion and exclusion criteria. in total,18,698 patients were included with 1,570 (8.3%) of patients experiencing an adverse dermatologic reaction. the incidence of stevens-johnson syndrome/toxic epidermal necrolysis was 0.04%. © 2017 by anais brasileiros de dermatologia.